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  5. Tocris Bioscience™ ABX 464

Tocris Bioscience™ ABX 464

Product Code. 18756436
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18756436 10 mg 10mg
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Product Code. 18756436 Supplier Tocris Bioscience™ Supplier No. 6460/10

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140.20 GBP valid until 2026-03-31
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Description

HIV RNA splicing modulator

ABX 464 is an HIV RNA splicing modulator; it selectively enhances the splicing of HIV RNA in infected human PBMCs and inhibits viral replication, with no global effect on cellular splicing. ABX 464 inhibits replication of HIV strains harboring mutations associated with drug-resistance. ABX 464 binds the cap binding complex (CBC) and upregulates miR-124 expression in vitro and decreases expression of miR-124 target genes, MCP-1, CXCL-1, SERPIN-E1 in macrophages. It also decreases the number of Th17 cells, as well as IL-6 soluble receptor in CD4+ T cells. In HIV infected humanized mice, treatment with ABX 464 reduces viral load. Anti-inflammatory.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 8-Chloro-N-[4-(trifluoromethoxy)phenyl]-2-quinolinamine
CAS 1258453-75-6
Quantity 10 mg
Target DNA, RNA and Protein Synthesis Compounds
Molecular Formula C16H10ClF3N2O
Purity 0.98
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