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Abrocitinib, MedChemExpress

Product Code. 16496827
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Quantity:
5 mg
10 mg
Unit Size:
10mg
5mg
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Product Code. 16496827

Brand: Medchem Express HY107429

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This item is not returnable. View return policy

Description

MedChemExpress Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

Specifications

Chemical Name or Material Abrocitinib
CAS 1622902-68-4
Color Yellow
Purity Grade Notes Research
Molecular Formula C14H21N5O2S
Quantity 5 mg
Synonym PF-04965842
Solubility Information DMSO : 125 mg/mL (386.51 mM; Need ultrasonic)
SMILES CN([C@H]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2
Molecular Weight (g/mol) 323.41
Formula Weight 323.41
Percent Purity 99.04%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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