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ABRA1 Recombinant Rabbit Monoclonal Antibody (JE62-73), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen MA544826

Additional Details : Weight : 0.01000kg

Product Code. 17838652

  • £383.00 / 100µL
Estimated Shipment: 19-08-2024
to see stock.

Description

Description

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
Specifications

Specifications

ABRA1
Recombinant Monoclonal
1 mg/mL
TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Q6UWZ7
Abraxas1
Synthetic peptide within human CCDC98 aa 360-409/409.
100 μL
Primary
Human
Liquid
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
JE62-73
Unconjugated
Abraxas1
3830405G04Rik; 5630400M01Rik; ABRA1; abraxas protein; Abraxas1; AI506069; AL024423; AV118690; BRCA1-A complex subunit Abraxas; BRCA1-A complex subunit Abraxas 1; Ccdc98; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; FAM175A; family with sequence similarity 175 member A; family with sequence similarity 175, member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A; RGD1305287; UNQ496/PRO1013
Rabbit
Protein A
RUO
84142
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
IgG
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