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Invitrogen™ ABRA1 Polyclonal Antibody

Product Code. 12818472
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Quantity:
100 μg
Unit Size:
100µg
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12818472 100 μg 100µg
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Product Code. 12818472 Supplier Invitrogen™ Supplier No. PA520412

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human breast tissue lysate. PA5-20412 can be used with blocking peptide PEP-0529.

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ABRA1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Abraxas1
Gene Accession No. Q6UWZ7, Q8BPZ8
Gene Alias 3830405G04Rik; 5630400M01Rik; ABRA1; abraxas protein; Abraxas1; AI506069; AL024423; AV118690; BRCA1-A complex subunit Abraxas; BRCA1-A complex subunit Abraxas 1; Ccdc98; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; FAM175A; family with sequence similarity 175 member A; family with sequence similarity 175, member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A; RGD1305287; UNQ496/PRO1013
Gene Symbols Abraxas1
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the amino terminus of human CCDC98.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 70681, 84142
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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