ABO, Blood Group A Antigen Antibody (HE-10), Novus Biologicals™

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
18199367	Novus Biologicals NBP2-44633-0.02MG	0.02 mg
18116728	Novus Biologicals NBP2-44633-0.1MG	0.1 mg

Description

Ensure accurate, reproducible results in Immunohistochemistry (Paraffin), Agglutination, Immunofluorescence

ABO, Blood Group A Antigen Monoclonal specifically detects ABO, Blood Group A Antigen in Human samples. It is validated for Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence, Agglutination.

Specifications

• Antigen: ABO, Blood Group A Antigen
• Concentration: 0.2 mg/mL
• Applications: Immunohistochemistry (Paraffin), Immunofluorescence, Agglutination
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: P16442
• Gene ID (Entrez): 28
• Immunogen: Mixture of erythrocytes of blood group A and glycoprotein fraction isolated from the saliva of secretors with blood group A
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.

• Clone: HE-10
• Dilution: Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, Immunofluorescence 0.5 - 1.0 ug/ml, Agglutination
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
• Gene Alias: A transferase, A3GALNT, A3GALT1, ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase;transferase B, alpha 1-3-galactosyltransferase), ABO glycosyltransferase, B transferase, B(A) alpha-1,3-galactosyltransferase, EC 2.4.1.37, EC 2.4.1.40, Fucosylglycoprotein 3-alpha-galactosyltransferase, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, Glycoprotein-fucosylgalactoside alpha-galactosyltransferase, Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase, GTB, Histo-blood group A transferase, histo-blood group A2 transferase, histo-blood group ABO system transferase, Histo-blood group B transferase, NAGAT
• Gene Symbols: ABO
• Isotype: IgM κ
• Purification Method: Protein A or G purified
• Test Specificity: This MAb preferably reacts with determinants of chain A and H type 3(Gal1-3GalNAc-R) and 4 (Gal1-3GalNAc-R), but not with type 1 and 2 chain structures. It is not reactive with immuno-dominant A trisaccharide. This MAb is applicable for tissue staining in tumor patients with blood groups A and AB. It shows a highly heterogeneous reactivity in human colon tumor tissue and adjacent mucosa. Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. The A, B and H antigens are reported to undergo modulation during malignant cellular transformation. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens.

For Research Use Only