Invitrogen™ ABCG4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA550289

Product Code. 15604225

Description

The antibody detects endogenous levels of total ABCG4 protein.

The ABCG4 gene encodes the ATP-binding cassette sub-family G member 4, a protein that is part of the ABC transporter family involved in the transport of various molecules across cellular membranes. ABC transporters play essential roles in lipid transport, drug resistance, and the maintenance of cellular homeostasis. ABCG4, specifically, is known to be involved in the transport of cholesterol and other lipids, influencing lipid homeostasis and potentially impacting processes such as cholesterol efflux and cellular lipid balance. This protein is expressed in specific tissues, including the brain and retina, indicating its role in neuronal lipid metabolism and health. While its exact physiological functions are still being elucidated, alterations in ABCG4 expression or function may be implicated in lipid-related disorders and neurodegenerative diseases, where lipid metabolism plays a crucial part. Research into ABCG4 focuses on understanding its transport mechanisms and potential contributions to pathological states, aiming to develop targeted therapies that address imbalances in lipid and cholesterol metabolism.

Specifications

• Antigen: ABCG4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Abcg4
• Gene Alias: 6430517O04Rik; ABCG4; ATP binding cassette subfamily G member 4; ATP-binding cassette sub-family G member 4; ATP-binding cassette, subfamily G (WHITE), member 4; ATP-binding cassette, sub-family G (WHITE), member 4; putative ABC transporter; WHITE2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 192663, 64137
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.9 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9H172
• Gene Symbols: Abcg4
• Immunogen: Fusion protein corresponding to residues near the N terminal of human ATP-binding cassette, sub-family G (WHITE), member 4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG