Invitrogen™ ABCA1 Monoclonal Antibody (3A1.891.3)

Rat Monoclonal Antibody

Brand:  Invitrogen™ MA116936

Product Code. 11584422

Description

This antibody does not react with human ABCA1.

Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

Specifications

• Antigen: ABCA1
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.1% sodium azide
• Gene Accession No.: O95477, P41233
• Gene Symbols: Abca1
• Immunogen: A1-N3 peptide (within residues 200-250) of mouse ABCA1 covalently linked to chicken egg albumin by means of glutaraldehyde.
• Regulatory Status: RUO
• Gene ID (Entrez): 11303, 19
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 3A1.891.3
• Conjugate: Unconjugated
• Gene: Abca1
• Gene Alias: ABC 1; ABC 1 antibody; ABC Transporter 1; Abc1; ABC-1; ABC1 antibody; Abca1; ATP binding cassette subfamily A member 1; ATP-binding cassette 1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; ATP-binding cassette, subfamily A (ABC1), member 1; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette, sub-family A member 1; CERP; CERP antibody; Cholesterol efflux regulatory protein; HDLDT1; membrane-bound; phospholipid-transporting ATPase ABCA1; phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; TGD
• Host Species: Rat
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1 κ