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  8. ABBV-744, MedChemExpress

ABBV-744, MedChemExpress

Product Code. 16450867
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Product Code. 16450867

Brand: Medchem Express HY112090

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Description

MedChemExpress ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of BET family proteins with IC50 values ranging from 4 to 18 nM for BRD2, BRD3, BRD4 and BRDT. ABBV-744 is primarily metabolized by CYP3A4 with drug-like properties enable the investigation of its antitumor efficacy and tolerability.

ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of BET family proteins with IC50 values ranging from 4 to 18 nM for BRD2, BRD3, BRD4 and BRDT. ABBV-744 is primarily metabolized by CYP3A4 with drug-like properties enable the investigation of its antitumor efficacy and tolerability.

Specifications

Chemical Name or Material ABBV-744
CAS 2138861-99-9
Color White
Purity Grade Notes Research
Molecular Formula C28H30FN3O4
Quantity 50 mg
Solubility Information DMSO : 100 mg/mL (203.44 mM; Need ultrasonic)
SMILES CC(O)(C)C1=CC(C(C2=C3NC(C(NCC)=O)=C2)=CN(C)C3=O)=C(OC4=C(C)C=C(F)C=C4C)C=C1
Molecular Weight (g/mol) 491.55
Formula Weight 491.55
Percent Purity 98.22%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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