STEMCELL Technologies A 83-01

Product Code.	Quantity	unitSize
17150012	5 mg	5mg
17109971	50 mg	50mg
17160012	10 mg	10mg

Produktkod. 17150012

Brand: STEMCELL Technologies 72022

Beskrivning

Activin/NODAL/TGF-β pathway inhibitor; Inhibits ALK5, ALK4, and ALK7

• A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC₅₀ = 12, 45, and 7.5 nM, respectively (Tojo et al.)
• Facilitates the conversion of epiblast stem cells to the naїve pluripotent state (Zhou et al.; Li et al.)
• In combination with PD0325901, enables OCT4-mediated reprogramming (Zhu et al.)
• Inhibits mesoderm and endoderm specification (Zhang et al.)
• Disrupts epithelial to mesenchymal transition through inhibition of the SMAD signaling pathway (Tojo et al.)

Specifikationer

• CAS: 909910-43-6
• Quantity: 5 mg
• Molecular Formula: C₂₅H₁₉N₅S
• Purity: ≥95%