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A-366, MedChemExpress

Product Code. 16411467
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Quantity:
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10 mg
50 mg
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50mg
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Product Code. 16411467

Brand: Medchem Express HY12583

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Description

MedChemExpress A-366 is a potent, highly selective, peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP (EHMT1), respectively.

A-366 shows >1000-fold selectivity over 21 other methyltransferases. A-366 is also a potent, nanomolar inhibitor of the Spindlin1-H3K4me3-interaction (IC50=182.6 nM). A-366 displays high affinity at human histamine H3 receptor (Ki=17 nM) and shows subtype selectivity among subsets of the histaminergic and dopaminergic receptor families.

Specifications

Chemical Name or Material A-366
CAS 1527503-11-2
Color Yellow
Purity Grade Notes Research
Molecular Formula C19H27N3O2
Quantity 50 mg
Solubility Information DMSO : 50 mg/mL (151.77 mM; Need ultrasonic)
SMILES COC1=CC2=C(N=C(N)C23CCC3)C=C1OCCCN4CCCC4
Molecular Weight (g/mol) 329.44
Formula Weight 329.44
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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