A-317491, MedChemExpress

Product Code. 16479197

Brand: Medchem Express HY15568

Description

MedChemExpress A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.

A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.

Specifications

• Chemical Name or Material: A-317491
• CAS: 475205-49-3
• Color: Pink
• Purity Grade Notes: Research
• Molecular Formula: C₃₃H₂₇NO₈
• Quantity: 5 mg
• Solubility Information: DMSO : ≥ 47 mg/mL (83.10 mM) ∣H2O : < 0.1 mg/mL (insoluble)
• SMILES: O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O
• Molecular Weight (g/mol): 565.57
• Formula Weight: 565.57
• Percent Purity: 98.25%
• Grade: Research
• Physical Form: Solid
• For Use With (Application): Cancer-programmed cell death

Research purposes only