Antibiotic A23187, 98%, Thermo Scientific™

An antibiotic and calcium ionophore

Brand:  Thermo Scientific Alfa Aesar J63020.MA

Product Code. 15465289

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Applications
A23187 (Mixed Calcium-Magnesium Salt) is used in cell activation experiments when calcium dose-response data are not required. Ca-Mg ratio ∼ 1:1. it is widely used as a compound in cell activation. It is used as a highly selective Ca2+ ionophore. it is used in studies of intracellular Ca2+ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation. A23187 is a widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intracellular levels of calcium. Visualization of Synaptic Ca2+ Calmodulin-Dependent Protein Kinase II Activity in Living Neurons.

Solubility
Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.

Specifications

• CAS: 52665-69-7
• Quantity: 10mg
• MDL Number: MFCD00151202,MFCD00151202
• Merck Index: 14,1639
• Solubility Information: Soluble in DMSO with warming or sonication; Also soluble in ethanol or ethyl acetate
• SMILES: CNC1=CC=C2OC(C[C@@H]3OC4(CC[C@@H]3C)O[C@H](C(C)C(=O)C3=CC=CN3)[C@H](C)C[C@H]4C)=NC2=C1C(O)=O
• Molecular Weight (g/mol): 523.63
• Formula Weight: 523.62
• Chemical Name or Material: Antibiotic A23187

• Color: White to Yellow
• Molecular Formula: C29H37N3O6
• Beilstein: 1096801
• Synonym: Calcimycin; Calcium ionophore A23187
• InChI Key: HIYAVKIYRIFSCZ-CVXKHCKVSA-N
• IUPAC Name: 5-(methylamino)-2-{[(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
• PubChem CID: 97043288
• Percent Purity: 98%