Suramin hexasodium salt, 98+%, Thermo Scientific™

Suramin hexasodium salt (suramin sodium, CAS # 129-46-4) is the sodium salt of suramin.

Brand:  Thermo Scientific Alfa Aesar J61707.MD

Product Code. 15454249

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Suramin is a polysulphonated napthylurea which exhibits anti-parasitic and anticancer properties

• Suramin prevents endothelial cell migration and proliferation through inhibition of IGF-I, EGF, PDGF, and TGF-beta

• Suramin can also uncouple G-proteins from receptors and turn off cell signaling cascades

Application

• Suramin inhibits angiogenesis through blockade of bFGF and VEGF and can be useful for the laboratory study of blood vessel growth and renewal following injury

• Suramin inhibits DNA topoisomerases, and can be used as an antineoplastic agent in the laboratory study of cancer or for studies of microbial physiology

Specifications

• CAS: 129-46-4
• MDL Number: MFCD00210217
• Beilstein: 3694087
• Synonym: suramin sodium, suramin hexasodium, suramin hexasodium salt, suramin sodium salt, antrypol, moranyl, naganinum, naphuride sodium, fourneau 309, suramine sodium salt
• InChI Key: VAPNKLKDKUDFHK-UHFFFAOYSA-H
• IUPAC Name: hexasodium 8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonate
• PubChem CID: 8514
• Percent Purity: ≥98%

• Molecular Formula: C51H34N6Na6O23S6
• Quantity: 250mg
• Merck Index: 14,9006
• Solubility Information: Soluble in water and saline; Sparingly soluble in 95% bethanol
• SMILES: [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC(NC(=O)NC2=CC(=CC=C2)C(=O)NC2=CC(=CC=C2C)C(=O)NC2=C3C(C=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C2)S([O-])(=O)=O)=CC=C1)C(=O)NC1=C2C(C=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C1)S([O-])(=O)=O
• Molecular Weight (g/mol): 1429.15
• Formula Weight: 1429.16
• Chemical Name or Material: Suramin hexasodium salt