Rapamycin, 99+%, Thermo Scientific™

Rapamycin, CAS # 53123-88-9, is a macrolide compound showing suppressor activity against the immune system and also exhibits inhibitory activity in tumor growth.

Brand:  Thermo Scientific Alfa Aesar J62473.MF

Product Code. 15444849

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Rapamycin is a natural macrolide compound showing antiproliferative activities in mammalian cells
• Rapamycin is a specific inhibitor of rapamycin kinase. It forms a complex with FKBP12 that consequently binds and inhibits rapamycin’s molecular target (rapamycin kinase)

Application

• Rapamycin inhibits tumor growth by preventing tumor cell proliferation and suppressing tumor angiogenesis
• This compound also blocks cytokine-mediated signal transduction pathways
• Rapamycin also promotes the suppression of the immune system
• It was initially defined as an antifungal metabolite produced by Streptomyces hygroscopicus
• In vitro studies demonstrated that this compound is an important mediator of PI3 kinase signaling

Specifications

• CAS: 53123-88-9
• Quantity: 50mg
• MDL Number: MFCD00867594
• Synonym: Sirolimus; AY-22989
• InChI Key: QFJCIRLUMZQUOT-HPLJOQBZSA-N
• Molecular Weight (g/mol): 914.187
• ChEBI: CHEBI:9168
• Percent Purity: ≥99%

• Color: White
• Molecular Formula: C51H79NO13
• Merck Index: 14,8114
• Solubility Information: Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol,dimethyl sulfoxide and dimethyl formamide; Insoluble in water.
• SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
• PubChem CID: 5284616
• Formula Weight: 914.17
• Chemical Name or Material: Rapamycin

Safety and Handling

Product Identifier

• Rapamycin

Signal Word

• Danger

Hazard Category

• Carcinogenicity Category 2
• Reproductive toxicity Category 2
• Specific target organ toxicity Category 1

Hazard Statement

• H351-Suspected of causing cancer.
• H361-Suspected of damaging fertility or the unborn child.
• H372-Causes damage to organs.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

Supplemental information

• MIXTURE LIST-Contains : Sirolimus