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  5. STEMCELL Technologies 8-Bromo-cAMP

STEMCELL Technologies 8-Bromo-cAMP

Product Code. 17120252
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Product Code. 17120252 Supplier STEMCELL Technologies Supplier No. 73604

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Description

cAMP pathway activator; Activates cAMP-dependent kinase

  • 8-Bromo-cAMP is a membrane-permeable cAMP derivative
  • It can activate cAMP-dependent protein kinase, with long-acting effects due to its resistance to cAMP phosphodiesterase (Schwede et al.) It can be used to study calcium-mediated pathways (IC50 = 0.84 mM; Xaus et al.) REPROGRAMMING
  • Improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells, in combination with vaLproic acid (Wang & Adjaye)
  • Inhibits M-CSF-dependent proliferation of macrophages (Xaus et al.)
  • Protects neutrophils against TNF-α-induced apoptosis (Krakstad)
  • Induces a proliferative response in an IL-3-dependent leukemic cell line (Barge et al.)
  • Induces membrane depolarization in pancreatic cancer cell lines (Sorio et al.)

Specifications

CAS 23583-48-4
Synonym 8-BrcAMP; 8-Bromoadenosine 3’,5’-cyclic monophosphate; NSC 171719
Quantity 100 mg
Molecular Formula C10H11BrN5O6P
Purity ≥95%
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