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TrxR1 Mouse anti-Human, Clone: 5A5, Invitrogen™

Product Code. 10202970
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Quantity:
100 μL
Unit Size:
100µg
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10202970 100 μL 100µg
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Product Code. 10202970 Supplier Invitrogen Supplier No. LFMA0020

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Description

Mouse Monoclonal Antibody

A suggested positive control for this product is HeLa cells.

The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxidoreductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence (-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55-58 kilodalton in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TrxR1
Applications ELISA, Immunoprecipitation
Classification Monoclonal
Clone 5A5
Conjugate Unconjugated
Gene TXNRD1
Gene Accession No. Q16881
Gene Alias trxR1
Gene Symbols TXNRD1
Host Species Mouse
Immunogen Purified, recombit, human thioredoxin reductase 1 protein expressed in E. coli.
Purification Method Ammonium sulfate precipitation
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7296
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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