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Tocris Bioscience™ (5Z)-7-Oxozeaenol
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Product Code. 18725187
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1mg
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Product Code. 18725187

Brand: Tocris Bioscience™ 3604/1

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Description

Potent and selective TAK1 MAPKKK inhibitor

(5Z)-7-Oxozeaenol is a resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-κB (IC50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.
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Specifications

Quantity 1 mg
Product Type (5Z)-7-Oxozeaenol
Purity >99%
Molecular Weight (g/mol) 362.37
Inhibitors (5Z)-7-Oxozeaenol

For Research Use Only

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