Invitrogen™ Phl p 1 Chimeric Recombinant Human Monoclonal Antibody (Clone 25)

Human Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA551651

Product Code. 30088471

Description

This antibody binds to the Timothy grass allergen Phl p 1 and shows cotss reactivity with natural group 1 allergens from a variety of grass species such as oat, sweet vernal grass, Bermuda grass, rye grass, common reed, Kentucky blue grass, rye, wheat and maize (weak).

Phl p 1 binds to specific receptors on the surface of immune cells called TLR4 (Toll-like receptor 4) and MD-2 (myeloid differentiation factor 2). This binding triggers a signaling cascade that leads to the activation of immune cells and the release of inflammatory mediators, which cause the allergic symptoms. The interaction between Phl p 1 and TLR4-MD-2 complex has been studied extensively and is considered a key event in the development of grass pollen allergy. Understanding the molecular mechanisms involved in this interaction is important for developing new therapeutic strategies to treat or prevent allergic reactions.

Specifications

• Antigen: Phl p 1 Chimeric
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Host Species: Human
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Target Species: Plant
• Product Type: Antibody
• Isotype: IgE κ

• Applications: Dot Blot, ELISA, Western Blot
• Clone: Clone 25
• Conjugate: Unconjugated
• Gene Alias: Group 1 grass pollen allergen; Phleum pratense allergen 1; Timothy grass pollen allergen
• Immunogen: Recombinant Phl p 1, a grass pollen allergen.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid