R&D Systems™ Recombinant Human NRG1/HRG1-alpha EGF domain Fc Protein

Product Code. 18796045

Brand: R&D Systems™ 11343NR500

Description

Fc Chimera

Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 4.00-40.0 ng/mL.

Specifications

• Accession Number: NP_039254.1
• For Use With (Application): Bioactivity
• Formulation: Lyophilized from a 0.2μm filtered solution in PBS with Trehalose.
• Gene ID (Entrez): 3084
• Molecular Weight (g/mol): M.W. (Observed): 36-43 kDa, under reducing conditions., M.W. (Theoretical): 32 kDa
• Quantity: 500 μg
• Source: Human embryonic kidney cell, HEK293-derived human Neuregulin-1/NRG1 protein Human NRG1/HRG1-alpha EGF domain (Ser177-Pro226) (N-terminus) Accession # NP_039254.1 IEGRMD Human IgG1 (Pro100-Lys330) (C-terminus)
• Storage Requirements: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Endotoxin Concentration: <0.10 EU per 1μg of the protein by the LAL method.
• Gene Alias: ARIA, GGF2, GGFglial growth factor, Heregulin-1, HGL, HGLneu differentiation factor, HRG, HRG1, HRG1-alpha, HRG1-beta 1, HRGAneuregulin 1 type IV beta 1a, MST131, MSTP131, NDFheregulin, alpha (45kD, ERBB2 p185-activator), neuregulin 1, neuregulin 1 type IV beta 3, Neuregulin1, NRG1, pro-neuregulin-1, membrane-bound isoform, pro-NRG1, sensory and motor neuron derived factor, SMDF
• Conjugate: Unconjugated
• Species: Human
• Reconstitution: Reconstitute at 500μg/mL in PBS.
• Purity or Quality Grade: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining.
• Protein: Neuregulin-1/NRG1