missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ ML 252

Tocris Bioscience™ ML 252
GREENER_CHOICE

Product Code. 18779206
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
This item is not returnable. View return policy

Product Code. 18779206

Brand: Tocris Bioscience™ 4687/50

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Potent and selective KV7.2 inhibitor; brain penetrant

ML 252 is a potent and selective inhibitor of KV7.2 voltage-gated potassium channels (IC50 = 70 nM), which displays >40-fold selectivity for KV7.2 over KV7.1 channels (IC50 = 2.9 μM for KV7.1). ML 252 is the (S)-enantiomer, and is more potent than the (R)-enantiomer or racemic mixture (IC50 values are 944 and 160 nM, respectively). ML 252 displays selectivity for KV7.2 over a panel of >68 GPCRs, ion channels and transporters; inhibits melatonin MT1 receptor 60% at 10 μM. ML 252 is brain penetrant.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
CAS 1392494-64-2
Quantity 50 mg
Target Voltage-gated Potassium Channel Blockers
Molecular Formula C20H24N2O
Purity 0.98
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.