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  5. Tocris Bioscience™ AMG 333

Tocris Bioscience™ AMG 333
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Product Code. 18797126
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18797126

Brand: Tocris Bioscience™ 6874/50

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Description

Potent and selective TRPM8 antagonist

AMG 333 is a potent and selective TRPM8 antagonist (IC50 values are 13 and 20 nM for hTRPM8 and rTRPM8, respectively). Displays high selectivity over other TRP channels (IC50 >20 μM, TRPV1/V3/V4/A1). Inhibits icilin -induced wet-dog shake in rats and suppresses cold-induced increases in blood pressure in the rat cold-pressor test.
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Specifications

Quantity 50 mg
Molecular Formula C20H12F5N3O4
Formula Weight 453.33
Product Type Antagonist
Purity 98%
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