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  5. Tocris Bioscience™ VAS 2870

Tocris Bioscience™ VAS 2870
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Product Code. 18737426
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Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
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Product Code. 18737426

Brand: Tocris Bioscience™ 6654/5

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Description

NADPH oxidase (Nox) inhibitor

VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC50 = 2 μM). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs in vitro. Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF-β-induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
CAS 722456-31-7
Quantity 5 mg
Molecular Formula C18H12N6OS
Formula Weight 360.39
Purity 98%
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