Thermo Scientific™ 5-Azacytidine, 99%

5-Azacytidine, CAS # 320-67-2, is an chemical analog of cytidine that acts as an inhibitor of DNA methyltransferase activity.

Brand:  Thermo Scientific™ 226620500

Product Code. 10003160

Description

This Thermo Scientific brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

5-Azacytidine is a chemical analog of the nucleoside cytidine that incorporates into DNA and inhibits DNA methylation

At low doses, 5-azacytidine irreversibly binds the enzyme DNA methyltransferase (DNMT)

Applications

5-Azacytidine has been used for cardiomyocyte differentiation from mesenchymal stem cells

It has been used as a potent DNMT inhibitor in the study of tumor cell proliferation and induction of gene expression following demethylation

5-Azacytidine can globally change histone modification patterns

Chemical Identifiers

• CAS: 320-67-2
• Molecular Weight (g/mol): 244.21
• InChI Key: NMUSYJAQQFHJEW-KVTDHHQDSA-N
• PubChem CID: 9444
• IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

• Molecular Formula: C₈H₁₂N₄O₅
• MDL Number: MFCD00006539
• Synonym: 5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin
• ChEBI: CHEBI:2038
• SMILES: C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N

Specifications

• Chemical Name or Material: 5-Azacytidine
• CAS: 320-67-2
• CAS Max %: 100.0
• Melting Point: 228.0°C to 230.0°C
• Infrared Spectrum: Authentic
• MDL Number: MFCD00006539
• Merck Index: 15, 884
• Quantity: 50mg
• InChI Key: NMUSYJAQQFHJEW-KVTDHHQDSA-N
• IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
• Molecular Weight (g/mol): 244.21
• ChEBI: CHEBI:2038
• Physical Form: Crystalline Powder

• Name Note: 99%
• CAS Min %: 98.5
• Color: White
• Assay Percent Range: 98.5% min. (HPLC)
• Molecular Formula: C₈H₁₂N₄O₅
• Packaging: Glass bottle
• Synonym: 5-azacytidine, azacitidine, ladakamycin, azacytidine, vidaza, mylosar, azacitidina, azacitidinum, 5-azacitidine, azacitidinum inn-latin
• Solubility Information: Solubility in water: .. Other solubilities: soluble in methanol
• SMILES: C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
• Specific Rotation: + 40.00
• PubChem CID: 9444
• Formula Weight: 244.21
• Percent Purity: 99%

Safety and Handling

Product Identifier

• 5-Azacytidine

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 4
• Germ cell mutagenicity Category 1B

Hazard Statement

• H340-May cause genetic defects.
• H302-Harmful if swallowed.

Precautionary Statement

• P201-Obtain special instructions before use.
• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only