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  5. STEMCELL Technologies 5-Azacytidine

STEMCELL Technologies 5-Azacytidine

Product Code. 17140012
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Product Code. 17140012 Supplier STEMCELL Technologies Supplier No. 72014

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Description

Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)

  • 5-Azacytidine is an analog of the nucleoside cytidine which can be incorporated into DNA and RNA
  • 5-Azacytidine acts as an epigenetic modifier by incorporating into DNA where it irreversibly binds to DNA methyltransferases, thus inhibiting their activity
  • Increases reprogramming efficiency of mouse fibroblasts to induced pluripotent stem (iPS) cells by inducing full reprogramming of partially reprogrammed cells (Mikkelsen et al.)
  • Resets epigenetic memory in mouse iPS cells, in combination with Trichostatin A (Kim et al.)
  • Enhances differentiation to cardiomyocytes from human embryonic stem cells (Yoon et al.)
  • Wide range of anti-metabolic activities when tested against cultured cancer cells and an effective chemotherapeutic agent for acute myelogenous leukemia

Specifications

CAS 320-67-2
Synonym 5-AzaC; Antibiotic U 18496; Ladakamycin; Mylosar; NSC 103-627; NSC 102816; U 18496; WR 183027; Zcyd
Quantity 250 mg
Molecular Formula C8H12N4O5
Purity ≥95%
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