5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside, 98%, Thermo Scientific Chemicals

Product Code.	Quantity	unitSize
15450387	50 mg	50mg
15440387	200 mg	200mg

Product Code. 15450387 Supplier Thermo Scientific Alfa Aesar Supplier No. J64720.MF

Description

Activator of AMP-activated protein kinase (AMPK)

5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside is used as a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes.

Solubility
Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml

Notes
Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Specifications

Chemical Identifiers

• CAS: 2627-69-2
• Molecular Formula: C9H14N4O5
• Molecular Weight (g/mol): 258.23
• MDL Number: MFCD00869751
• InChI Key: RTRQQBHATOEIAF-UUOKFMHZSA-N
• Synonym: acadesine, aica-riboside, aicar, arasine, aica riboside, aic-riboside, acadesina, acadesinum, 5-amino-1-beta-d-ribofuranosyl-1h-imidazole-4-carboxamide, protara
• PubChem CID: 17513
• ChEBI: CHEBI:28498
• IUPAC Name: 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide
• SMILES: NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

• Melting Point: 214°C to 215°C
• Color: Brown
• Quantity: 50 mg
• Merck Index: 14,16
• Solubility Information: Soluble in DMSO at 2mg/ml; Soluble in water or ethanol at less than 1mg/ml
• Formula Weight: 258.23
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside

Safety and Handling

Product Identifier

• 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Supplemental information

• MIXTURE LIST-Contains : 5-amino-1-.beta.-D-ribofuranosyl-1H-Imidazole-4-carboxamide

SDS

RUO – Research Use Only