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  7. 4-Hydroxyquinazoline, 98%

4-Hydroxyquinazoline, 98%

Product Code. 11448996
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Quantity:
10 g
50 g
Unit Size:
10g
50g
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Product Code. 11448996

Brand: Thermo Scientific Alfa Aesar A17129.09

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Description

CAS: 491-36-1 | C8H6N2O | 146.149 g/mol

4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.

Solubility
Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 491-36-1
Molecular Formula C8H6N2O
Molecular Weight (g/mol) 146.149
MDL Number MFCD00511302
InChI Key QMNUDYFKZYBWQX-UHFFFAOYSA-N
Synonym 4-hydroxyquinazoline, 4-quinazolinol, quinazolin-4-ol, quinazolin-4 3h-one, 4 3h-quinazolinone, 4-quinazolone, 4-quinazolinone, 4 1h-quinazolinone, 4-oxoquinazoline, 3,4-dihydroquinazolin-4-one
PubChem CID 63112
IUPAC Name 1H-quinazolin-4-one
SMILES C1=CC=C2C(=C1)C(=O)N=CN2

Specifications

Melting Point 216°C to 219°C
Odor Odorless
Quantity 10 g
Beilstein 118473
Solubility Information Soluble in DMSO (100 mM),ethanol,methanol,and water (10 mM).
Formula Weight 146.15
Percent Purity 98%
Chemical Name or Material 4-Hydroxyquinazoline

RUO – Research Use Only

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