Thermo Scientific Chemicals 4-Epitetracycline hydrochloride, can be used as a secondary standard

Product Code.	Quantity	Packaging	unitSize
10358320	100 mg	Glass bottle	100mg
10318370	500 mg	Glass bottle	500mg

Product Code. 10358320

Brand: Thermo Scientific Chemicals 233121000

Description

4-Epitetracycline hydrochloride, CAS # 23313-80-6, is a degradation product of tetracycline that shows antibiotic activity and can induce the protein biosynthesis inhibition.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 4-Epitetracycline hydrochloride is a metabolite derived from the degradation of tetracycline compounds and has been shown to display antibiotic activity
• This compound blocks protein synthesis by binding to the 30S ribosomal subunit and interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex

Applications

• This semi-synthesized compound derived from actinomycetes can decrease the activity of the Tet repressor effector in animal models
• In vivo experiments revealed that 4-epitetracycline hydrochloride can induce a toxic response

Specifications

Chemical Identifiers

• CAS: 23313-80-6
• Molecular Formula: C₂₂H₂₄N₂O₈·HCl
• Molecular Weight (g/mol): 480.89
• MDL Number: MFCD00865028
• InChI Key: YCIHPQHVWDULOY-DXDJYCPMSA-N
• Synonym: 4-epitetracycline hydrochloride, epitetracycline hydrochloride, 4-epi-tetracycline hydrochloride, quatrimycin hydrochloride, epitetracycline hcl, unii-i7c3edl2yg, i7c3edl2yg, epitetracycline hydrochloride usp, 4r,4as,5as,6s,12as-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
• PubChem CID: 54686189
• IUPAC Name: (4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride
• SMILES: CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.Cl

• Melting Point: 217.0°C
• Color: Yellow
• Infrared Spectrum: Authentic
• Assay Percent Range: 80% min. (as is,calculated)
• Packaging: Glass bottle
• Quantity: 100 mg
• Specific Rotation: − 322.00
• Solubility Information: Solubility in water: 100g/L. Other solubilities: 100g/L methanol
• Formula Weight: 480.89
• Percent Purity: ≥97.0% Total Base (on anhydrous substance), ≥80 wt% (as is, calculated) (HPLC)
• Physical Form: Fine Crystalline Powder
• Chemical Name or Material: 4-Epitetracycline hydrochloride

Sicherheit und Handhabung

Produktidentifikator

• 4-Epitetracycline hydrochloride

Signalwort

• Warning

Gefahrenkategorie

• Serious eye damage/eye irritation Category 2
• Reproductive toxicity Category 2

Gefahrenhinweis

• H361d-Suspected of damaging the unborn child.
• H319-Causes serious eye irritation.

Sicherheitshinweis

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Sicherheitsdatenblatt (SDS)

RUO – Research Use Only