Thermo Scientific Chemicals 4-Epianhydrotetracycline hydrochloride, can be used as a secondary standard

Product Code.	Quantity	Packaging	unitSize
10073170	100 mg	Glass bottle	100mg
10751891	500 mg	Glass bottle	500mg

Product Code. 10073170

Brand: Thermo Scientific Chemicals 233111000

Description

4-Epianhydrotetracycline hydrochloride, CAS # 4465-65-0, is an antibiotic derivative of tetracycline. It is an important standard for monitoring tetracycline stability and toxicity in laboratory studies.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• 4-Epianhydrotetracycline hydrochloride is a secondary degradation product formed by epimerization of tetracycline and dehydration at the C6 position to aromatize the B ring
• It has 250-fold higher toxicity than either tetracycline or doxycycline depending on the system under study

Applications

• 4-Epianhydrotetracycline hydrochloride is less toxic to E. coli, and thus suitable for use with vectors or systems designed upon elements of the (Tn10) tet operon of E. coli
• This compound is also used in veterinary medicine research and as a secondary standard for application in quality control in pharmaceutical laboratories

Specifications

Chemical Identifiers

• CAS: 4465-65-0
• Molecular Formula: C₂₂H₂₂N₂O₇·HCl
• Molecular Weight (g/mol): 462.89
• MDL Number: MFCD00151455
• InChI Key: SPFAOPCHYIJPHJ-MOMXNFOMSA-N
• Synonym: 4-epianhydrotetracycline hydrochloride, unii-06y7hm8dba, 06y7hm8dba, 4-epi-anhydrotetracycline hydrochloride, 4-epi-ahydrochloride, 4-epianhydrotetracycline hcl, epianhydrotetracycline hydrochloride, 4-epianhydrotetracycline hydrochloride, vetranal tm , analytical standard, 4-epianhydrotetracycline hydrochloride, european pharmacopoeia ep reference standard, 4-epianhydrotetracycline hydrochloride, united states pharmacopeia usp reference standard
• PubChem CID: 54682545
• IUPAC Name: (4R,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide;hydrochloride
• SMILES: CC1=C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C.Cl

• CAS Min %: 96.0
• CAS Max %: 100.0
• Melting Point: 220.0°C
• Color: Orange
• Infrared Spectrum: Authentic
• Assay Percent Range: 80% min. (as is,calculated)
• Packaging: Glass bottle
• Quantity: 100 mg
• Specific Rotation: − 279.00
• Solubility Information: Solubility in water: 0.9g/L. Other solubilities: 25g/L methanol
• Formula Weight: 462.89
• Percent Purity: ≥97.0% Total Base (on anhydrous substance), ≥80 wt% (as is, calculated) (HPLC)
• Physical Form: Powder
• Chemical Name or Material: 4-Epianhydrotetracycline hydrochloride, 97%

Safety and Handling

Product Identifier

• 4-Epianhydrotetracycline hydrochloride

Signal Word

• Warning

Hazard Category

• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 2
• Reproductive toxicity Category 2

Hazard Statement

• H319-Causes serious eye irritation.
• H361d-Suspected of damaging the unborn child.
• H302-Harmful if swallowed.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

SDS

RUO – Research Use Only