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STAT5 alpha/beta Rabbit anti-Hamster, Human, Mouse, Polyclonal, Invitrogen™

Product Code. 11500213
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Quantity:
100 μg
Unit Size:
100µg
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11500213 100 μg 100µg
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Product Code. 11500213 Supplier Invitrogen Supplier No. OPA103010

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Description

Rabbit Polyclonal Antibody

OPA1-03010 detects signal transducer and activator of transcription 5 a/b (STAT5) from human, mouse, and hamster tissues and cells. Rat tissues are expected to react based on sequence homology. This antibody is specific for STAT5 and does not cross-react with any other STATs or related proteins. OPA1-03010 has been successfully used in western blot procedures. By western blot, this antibody detects an ∽92 and ∽85 kDa protein representing STAT5a and STAT5b, respectively, from CTLL cell lysate. OPA1-03010 was raised against a synthetic peptide derived from an internal region of human STAT5. The sequence of the immunogen is identical in rat.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen STAT5 alpha/beta
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation Dulbecco′s PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide; pH 7.3
Gene STAT5A
Gene Accession No. P42229, P51692, P42230, P42232
Gene Alias Signal Transducers and Activators of Transcription 5, MGF
Gene Symbols LOC100755571, STAT5A, Stat5b
Host Species Rabbit
Immunogen Synthetic Peptide derived from an internal region of human STAT5.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100755571, 20850, 20851, 6776, 6777
Target Species Hamster, Human, Mouse
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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