Invitrogen™ 20S Proteasome Monoclonal Antibody (863437)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA562036

Product Code. 30536232

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

The 20S proteasome is a core component of the proteasome complex, which plays a crucial role in the degradation of intracellular proteins. This multi-subunit protease complex is essential for maintaining cellular homeostasis by selectively degrading misfolded, damaged, or unneeded proteins, thus regulating various cellular processes, including the cell cycle, signaling pathways, and stress responses. The 20S proteasome is composed of 28 subunits arranged in a barrel-shaped structure with two outer alpha-rings and two inner beta-rings, which house the proteolytic active sites. Proteins targeted for degradation are typically tagged with ubiquitin molecules, recognized by the regulatory 19S cap complex, and then translocated into the 20S core for proteolysis. The proper functioning of the 20S proteasome is vital for cellular health, and its dysfunction is associated with a range of diseases, including neurodegenerative disorders like Alzheimer's and Parkinson's disease, where protein aggregation occurs, and cancer, where proteasome inhibitors are used as therapeutic agents. Understanding the structure, function, and regulation of the 20S proteasome is key for developing new therapeutic strategies aimed at modulating proteasome activity for the treatment of various diseases. Research into the 20S proteasome continues to provide insights into its broader role in cellular physiology and its potential as a target for drug development.

Specifications

• Antigen: 20S Proteasome
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with trehalose and no preservative
• Immunogen: Human 20S Proteasome purified from human erthrocytes.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized

• Applications: Western Blot, Immunocytochemistry
• Clone: 863437
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b