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Tocris Bioscience™ 20(S)-Hydroxycholesterol
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Product Code. 18096032
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10 mg
Unit Size:
10mg
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Product Code. 18096032 Supplier Tocris Bioscience™ Supplier No. 4474/10

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Description

Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation

Allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein; binds at a site distinct from the canonical cyclopamine binding site. Activates Hedgehog (Hh) signaling (EC50 ∽ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). Induces Smo accumulation in primary cilia; also exhibits osteogenic activity and activates the liver X receptor (LXR).
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Specifications

CAS 516-72-3
Quantity 10 mg
Molecular Formula C27H46O2
Formula Weight 402.65
Purity >95%
Molecular Weight (g/mol) 402.663
Chemical Name or Material 20(S)-Hydroxycholesterol
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