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Thermo Scientific™ TheraPure™ 2'-Fluoro-U Phosphoramidite, 20-400 finish bottle

Product Code. 17907192 Shop All Thermo Scientific Products
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Product Code. 17907192 Supplier Thermo Scientific™ Supplier No. 27160209

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Description

2'-Fluoro-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-Fluoro protection, for use in oligonucleotide synthesis.

2'-Fluoro-U CEP is a phosphoramidite containing 5' DMT and the nucleoside uridine (U) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The TheraPure trademark denotes our highest level of phosphoramidite purity, developed with the greatest stringency of high definition analytics and tightly controlled impurity profiles and, therefore, ideal for any therapeutic application. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.

Features:
• Full chemical name: 5'-O-(4,4'-Dimethoxytrityl)-2'-fluorouridine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula: C39H46FN4O8P
• Base: A
• Formula weight: 748.8 g/mol
• CAS number: 146954-75-8
• HPLC purity: >98%
• 31P NMR purity: ≥98%

TRUSTED_SUSTAINABILITY

Specifications

For Use With (Equipment) Expedite Synthesizers
Product Type 2in-Fluoro-U CEP
Content And Storage Store in freezer (at or below -20°C).
Nucleoside Type Uridine (U)
Reagent Features 2in-Fluoro modified
Shipping Condition Room Temperature
Purity 98%
Quantity 0.25 g
Reagent Type Phosphoramidite
Grade TheraPure™
Nucleic Acid Type RNA
Product Line TheraPure
Form Powder
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For Research Use Only. Not for use in diagnostic procedures.

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