Thermo Scientific™ 2'-Fluoro-Bz-A Phosphoramidite, standard grade, 28-400 finish bottle

2'-Fluoro-Bz-A CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with 2'-Fluoro protection, for use in oligonucleotide synthesis.

Brand:  Thermo Scientific™ 27-1601-12

Product Code. 17917192

Description

2'-Fluoro-Bz-A CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The 'standard grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers.

Features:
• Full chemical name: 5'-O-(4,4'-Dimethoxytrityl)-N⁶-benzoyl-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula: C₄₇H₅₁FN₇O₇P
• Base: A
• Base Protection: Bz
• Formula weight: 875.92 g/mol
• HPLC purity: >98%
• ³¹P NMR purity: ≥98%

Specifications

• For Use With (Equipment): MerMade Synthesizers
• Content And Storage: Store in freezer (at or below -20°C).
• Reagent Features: 2in-Fluoro modified
• Purity: 98%
• Reagent Type: Phosphoramidite
• Nucleic Acid Type: RNA

• Product Type: 2in-Fluoro-Bz-A CEP
• Nucleoside Type: Adenosine (A)
• Shipping Condition: Room Temperature
• Quantity: 0.5 g
• Grade: Standard
• Form: Powder