Thermo Scientific™ 2'-Fluoro-Bz-A Phosphoramidite, standard grade, 20-400 finish bottle

Product Code. 17964272

Brand: Thermo Scientific™ 27160109

Description

2'-Fluoro-Bz-A CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with 2'-Fluoro protection, for use in oligonucleotide synthesis.

2'-Fluoro-Bz-A CEP is a phosphoramidite containing 5' DMT and the nucleoside adenosine (A) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. This product is supplied in a 30-mL amber bottle with a 20-400 finish neck style, which is compatible with most Expedite synthesizers.

Specifications

• 31P NMR Purity: ≥98%
• Format: Amber bottle (20-400 finish neck style)
• For Use With (Equipment): Expedite Synthesizers
• Description: Base: A
  Base Protection: Bz
• Molecular Weight (g/mol): 875.92 g/mol
• Product Type: 2in-Fluoro-Bz-A CEP
• Content And Storage: Store in freezer (at or below -20°C).
• Nucleoside Type: Adenosine (A)
• Reagent Features: 2in-Fluoro modified
• Shipping Condition: Room Temperature
• Purity: >98% (HPLC)
• Quantity: 0.25 g
• Reagent Type: Phosphoramidite
• Grade: Standard
• Nucleic Acid Type: RNA
• For Use With (Application): Oligonucleotide synthesis
• Form: Powder
• Chemical Name or Material: 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular Formula: C₄₇H₅₁FN₇O₇P

For Research Use Only. Not for use in diagnostic procedures.