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Tocris Bioscience™ 2-Deoxy-D-glucose

Product Code. 18013922
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Quantity:
50 mg
Unit Size:
50mg
Product Code. Quantity unitSize
18013922 50 mg 50mg
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Product Code. 18013922

Brand: Tocris Bioscience™ 4515/50

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Description

Non-metabolizable glucose analog; hexokinase substrate

2-Deoxy-D-glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR). 2-Deoxy-D-glucose disrupts N-glycan expression on the surface of pancreatic adenocarcinoma cells. 2-Deoxy-D-glucose enhances chimeric antigen receptor T cell activity in different xenograft mouse models of pancreatic adenocarcinoma cells.
TRUSTED_SUSTAINABILITY

Specifications

CAS 154-17-6
Quantity 50 mg
Molecular Formula C6H12O5
Formula Weight 164.16
Purity >98%
Molecular Weight (g/mol) 164.16
Chemical Name or Material 2-Deoxy-D-glucose
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