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Tocris Bioscience™ 142D6

Product Code. 30243660
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5 mg
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Product Code. 30243660

Brand: Tocris Bioscience™ 8018/5

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This item is not returnable. View return policy

Description

Potent Lys-covalent pan-IAP inhibitor

142D6 is a potent pan-IAP inhibitor (IC50 values are 21, 21 and 43 nM for cIAP1, cIAP2 and XIAP respectively). 142D6 covalently targets Lys residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family. In vitro, 142D6 reduces viability of cultured breast cancer MDA-MB-231 cells (EC50 values are 44 and 61 nM in cell viability and apoptosis assays, respectively). 142D6 is chemically stable in buffer and plasma and is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (R)-1-((S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-2,3-dihydro-1H-inden-4-yl sulfurofluoridate
CAS 2410953-19-2
Quantity 5 mg
Target IAP Inhibitors
Molecular Formula C26H37FN4O6S
Purity 95%
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