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Tocris Bioscience™ UBP 302
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Product Code. 30001294
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 30001294

Brand: Tocris Bioscience™ 2079/10

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This item is not returnable. View return policy

Description

Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)

Potent and selective GluK1 (formally GluR5)-subunit containing kainate receptor antagonist (apparent KD = 402 nM); active enantiomer of UBP 296 (Cat. No. 2078). Displays ∽ 260-fold selectivity over AMPA receptors, ∽ 90-fold selectivity over recombinant human GluK2 (formally GluR6) and GluK5 (formally KA2)-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

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Chemical Identifiers

CAS 745055-91-8
Molecular Formula C15H15N3O6

Specifications

Quantity 10 mg
Formula Weight 333.3
Purity >98%
Molecular Weight (g/mol) 333.3
Chemical Name or Material UBP 302
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