Tocris Bioscience™ SPRi 3

Product Code. 18788056

Brand: Tocris Bioscience™ 6597/10

Description

Potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR); attenuates proliferation of CD4+ T cells

SPRi 3 is a potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.

Specifications

• Chemical Name or Material: N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
• CAS: 1292285-54-1
• Quantity: 10 mg
• Molecular Formula: C₁₄H₁₈N₂O₃
• Formula Weight: 262.3
• Purity: 98%