Thermo Scientific HPLC columns for characterizing biopharmaceutical molecules


Get the innovative, high resolution, analytic HPLC columns, to detect, characterize and quantify structural variants and modifications in proteins, mAbs therapeutics and other biomolecules.

The broad range of HPLC columns provides users with the needed resolution to achieve a wide range of analytical tasks, such as:

  • Purity and titer analysis
  • Aggregation analysis
  • Charge variant analysis
  • Clips and truncations
  • Light chain/heavy chain analysis
  • Peptide mapping
  • Glycan profiling
  • Oligonucleotide separations
  • Post-translational modification analysis (amino acid substitutions/truncations, deamidation, phosphorylation, etc.)

Innovative, high resolution, fast, reliable, reproducible

Monoclonal Antibody HPLC Columns

Characterization of mAbs and their aggregates, fragments, and titers

Extensive development of protein and monoclonal antibody (mAb) therapeutics currently underway requires innovative and efficient tools that characterize and quantify structural variants and modifications, monitor product stability and demonstrate safety and efficacy. These specifically designed Thermo Scientific™ MAbPac™ columns provide a full range of high resolution, high efficiency mAb analyses by LC and LC-MS.

MAbPac Columns Primer Brochure [PDF] »

MAbPac RP Ordering Guide [PDF] »

MAbPac RP Columns [PDF] »

Oligonucleotide HPLC Columns

Exceptionally high resolution of +1 and -1 nucleic acids, including isomers

These columns are used in HPLC and UHPLC experiments. What sets Thermo Scientific™ DNAPac™ columns apart from the rest is their ability to provide exceptionally high resolution separations of nucleic acids (+1 and -1), including isomers, which is not possible with reversed phase columns. The larger i.d. columns are popularly used for the small scale purification of nucleic acids.

DNAPac Column brochure [PDF] »

Protein HPLC Columns

Exceptionally high resolution, high efficiency protein characterization 

High resolution and high efficiency set these columns apart. For excellent analytical characterization of proteins, we offer a full range of Thermo Scientific™ affinity, ion exchange, reversed phase, hydrophobic interaction, and size exclusion columns for your protein sample.

PepSwift and ProSwift brochure [PDF] »

Glycan HPLC Columns

Exceptional characterization, purification and isolation

Mixed-mode Thermo Scientific™ GlycanPac™ columns provide uniquely exceptional high resolution separation of neutral and charged glycans. In addition, we offer traditional amide-HILIC columns for the separation of neutral glycans, and ligand exchange columns for the purification and isolation of carbohydrates using an affinity support.

Glycan Carbohydrate HPLC Columns

These columns analyze both neutral and charged glycans. Use the traditional amide HILIC columns to separate neutral glycans, and the GlycanPac columns for exceptional high resolution separation of both neutral and charged glycans.

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GlycanPac AXR-1-(7)

Ligand Exchange Carbohydrate HPLC Columns

Need a column to separate carbohydrates using dilute acid mobile phase? These polymeric ligand exchange columns utilize a range of counter ions to deliver selectivity required.

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