CAS RN 1597403-47-8

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Molecular Weight (g/mol)

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ISRIB, TRC

CAS: 1597403-47-8 Molecular Formula: C22H24Cl2N2O4 Molecular Weight (g/mol): 451.34 Synonym: N,N'-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide],SMDC 750213 SMILES: Clc1ccc(OCC(=O)N[C@@H]2CC[C@H](CC2)NC(=O)COc3ccc(Cl)cc3)cc1

Pricing and Availability
Specifications

CAS	1597403-47-8
Molecular Weight (g/mol)	451.34
SMILES	Clc1ccc(OCC(=O)N[C@@H]2CC[C@H](CC2)NC(=O)COc3ccc(Cl)cc3)cc1
Synonym	N,N'-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide],SMDC 750213
Molecular Formula	C22H24Cl2N2O4

ISRIB (trans-isomer), MedChemExpress

MedChemExpress ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	451.34
Color	White
Physical Form	Solid
Chemical Name or Material	ISRIB (trans-isomer)
Grade	Research
SMILES	O=C(N[C@H]1CC[C@H](NC(COC2=CC=C(Cl)C=C2)=O)CC1)COC3=CC=C(Cl)C=C3.[Relative stereochemistry]
For Use With (Application)	Neuroscience-Neurodegeneration
Percent Purity	98.0%
CAS	1597403-47-8
Solubility Information	DMSO : 4.55 mg/mL (10.08 mM; ultrasonic and warming and heat to 60°C)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₂₄Cl₂N₂O₄
Formula Weight	451.34

CAS RN 1597403-47-8

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