CAS RN 1316755-16-4

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Olodanrigan, MedChemExpress

MedChemExpress Olodanrigan (EMA401) is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

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Specifications

Molecular Weight (g/mol)	507.58
Color	White
Physical Form	Solid
Chemical Name or Material	Olodanrigan
Grade	Research
SMILES	O=C([C@H]1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(C(OCC5=CC=CC=C5)=C(OC)C=C4)C1)O
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	99.16%
CAS	1316755-16-4
Solubility Information	DMSO : ≥ 34 mg/mL (66.98 mM) ∣H2O : 0.1 mg/mL (0.20 mM; Need ultrasonic)
Health Hazard 1	H302∣H315∣H319∣H335
Synonym	EMA401 PD-126055
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₂H₂₉NO₅
Formula Weight	507.58

CAS RN 1316755-16-4

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