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CAS RN 1195765-45-7

CAS RN 1195765-45-7

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1

Dabrafenib, TRC

CAS: 1195765-45-7 Molecular Formula: C23H20F3N5O2S2 Molecular Weight (g/mol): 519.56 Synonym: N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide,Dabarefenib,GSK 2118436,Tafinlar,GSK 2118436A IUPAC Name: N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide SMILES: CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F

CAS 1195765-45-7
Molecular Weight (g/mol) 519.56
SMILES CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
Synonym N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide,Dabarefenib,GSK 2118436,Tafinlar,GSK 2118436A
IUPAC Name N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
Molecular Formula C23H20F3N5O2S2
2

STEMCELL Technologies Dabrafenib

MEK/ERK pathway inhibitor; Inhibits B-RAF V600E

ENCOMPASS_PREFERRED
CAS 1195765-45-7
Purity ≥98%
Molecular Formula C23H20F3N5O2S2
3

Dabrafenib, MedChemExpress

MedChemExpress Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 519.56
Color Off-White
Physical Form Solid
Chemical Name or Material Dabrafenib
Grade Research
SMILES CC(C)(C)C1=NC(C2=C(F)C(NS(C3=C(F)C=CC=C3F)(=O)=O)=CC=C2)=C(C4=CC=NC(N)=N4)S1
For Use With (Application) Cancer-Kinase/protease
Percent Purity 95.0%
CAS 1195765-45-7
Solubility Information DMSO : ≥ 33 mg/mL (63.52 mM)
Synonym GSK2118436A GSK2118436
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C23H20F3N5O2S2
Formula Weight 519.56