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CAS RN 1146699-66-2

CAS RN 1146699-66-2

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1 – 5 of 5 results
1

(R)-2-[[4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide, TRC

High-purity organic molecules and analytical standards, strategically delivered worldwide to empower innovation and commercial success.

2

(R)-2-[[4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide, TRC

High-purity organic molecules and analytical standards, strategically delivered worldwide to empower innovation and commercial success.

3

Tocris Bioscience™ Avagacestat
GREENER_CHOICE

Highly potent γ-secretase inhibitor; orally bioavailable

CAS 1146699-66-2
Purity 98%
Chemical Name or Material (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Recommended Storage Store at 4°C
Synonym BMS-708163
Molecular Formula C20H17ClF4N4O4S
Formula Weight 520.89
4

(R)-2-[[4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide, TRC

High-purity organic molecules and analytical standards, strategically delivered worldwide to empower innovation and commercial success.

5

Avagacestat, MedChemExpress

MedChemExpress Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 μM. Avagacestat can be used for Alzheimer disease research.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 520.89
Color White
Physical Form Solid
Chemical Name or Material Avagacestat
Grade Research
SMILES O=S(N([C@@H](C(N)=O)CCC(F)(F)F)CC1=CC=C(C2=NOC=N2)C=C1F)(C3=CC=C(Cl)C=C3)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 95.0%
CAS 1146699-66-2
Solubility Information DMSO : ≥ 100 mg/mL (191.98 mM)
Synonym BMS-708163
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H17ClF4N4O4S
Formula Weight 520.89