CAS RN 1146699-66-2

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Tocris Bioscience™ Avagacestat

Highly potent γ-secretase inhibitor; orally bioavailable

Pricing and Availability
Specifications

CAS	1146699-66-2
Purity	98%
Chemical Name or Material	(2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide
Recommended Storage	Store at 4°C
Synonym	BMS-708163
Molecular Formula	C₂₀H₁₇ClF₄N₄O₄S
Formula Weight	520.89

Avagacestat, MedChemExpress

MedChemExpress Avagacestat (BMS-708163) is a potent inhibitor of γ-secretase, with IC50s of 0.27 nM and 0.30 nM for Aβ42 and Aβ40 inhibition; Avagacestat (BMS-708163) also inhibits NICD (Notch IntraCellular Domain) with IC50 of 0.84 nM and shows weak inhibition of CYP2C19, with IC50 of 20 μM. Avagacestat can be used for Alzheimer disease research.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	520.89
Color	White
Physical Form	Solid
Chemical Name or Material	Avagacestat
Grade	Research
SMILES	O=S(N([C@@H](C(N)=O)CCC(F)(F)F)CC1=CC=C(C2=NOC=N2)C=C1F)(C3=CC=C(Cl)C=C3)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	95.0%
CAS	1146699-66-2
Solubility Information	DMSO : ≥ 100 mg/mL (191.98 mM)
Synonym	BMS-708163
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₀H₁₇ClF₄N₄O₄S
Formula Weight	520.89

CAS RN 1146699-66-2

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