CAS RN 1103522-45-7
CAS RN 1103522-45-7
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N-Despropyl-macitentan, TRC
CAS: 1103522-45-7 Molecular Formula: C16H14Br2N6O4S Molecular Weight (g/mol): 546.19 Synonym: N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-sulfamide, ACT-132577 SMILES: O=S(N)(NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O
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Aprocitentan, MedChemExpress
MedChemExpress Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively.
