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Pyrroles

Aromatic organic heterocyclic compounds that consist of a five-membered ring with four carbon atoms and one nitrogen atom that forms an amine functional group.

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Indibulin, MedChemExpress

MedChemExpress Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis.

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Molecular Weight (g/mol) 389.83
Color Light Yellow
Physical Form Solid
Chemical Name or Material Indibulin
Grade Research
SMILES O=C(NC1=CC=NC=C1)C(C2=CN(CC3=CC=C(Cl)C=C3)C4=C2C=CC=C4)=O
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.47%
CAS 204205-90-3
Solubility Information DMSO : 50 mg/mL (128.26 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Synonym ZIO 301 D 24851
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C22H16ClN3O2
Formula Weight 389.83
2

Indoximod, MedChemExpress

MedChemExpress Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer.

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