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Invitrogen™ ZO-3 Polyclonal Antibody

Product Code. 10139582
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Quantity:
100 μg
Unit Size:
100µg
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10139582 100 μg 100µg
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10139582 Supplier Invitrogen™ Supplier No. 364000

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Rabbit Polyclonal Antibody

36-4000 was used successfully in the western blot analysis of ZO-3 in MDCK cell lysate.

ZO-3 is a member of the membrane associated guanylate kinse (MAGUK) family and are considered tight junction-associated proteins. Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. ZO-3 is believed to have both structural and signaling roles, and is characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ZO-3
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene TJP3
Gene Accession No. O62683, O95049, Q9QXY1
Gene Alias tight junction protein 3; tight junction protein 3 (zona occludens 3); tight junction protein ZO-3; TJP3; TJP-3; ZO3; ZO-3; Zona occludens protein 3; zonula occludens protein 3
Gene Symbols TJP3
Host Species Rabbit
Immunogen Synthetic peptide derived from an internal region of the human ZO-3 protein.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27134, 27375, 314640, 403852
Target Species Human, Mouse, Rat, Canine
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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