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Invitrogen™ Zap-70 Monoclonal Antibody (1E7.2), Alexa Fluor™ 488
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Product Code. 10008502
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500 μL
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10008502 500 μL Each
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For Research Use Only. All usage must comply with product instructions.
 
Product Code. 10008502 Supplier Invitrogen™ Supplier No. MHZAP7020

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This item is not returnable. View return policy
For Research Use Only. All usage must comply with product instructions.
 

Description

Mouse Monoclonal Antibody

Based on our testing, publications, and results reported from customers, the Alexa Fluor™ 488 dye provides the best fluorescein (FITC) substitute.

ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Zap-70
Applications Flow Cytometry
Classification Monoclonal
Clone 1E7.2
Conjugate Alexa Fluor 488
Formulation PBS with 4mg/mL BSA and 0.1% sodium azide
Gene ZAP70
Gene Accession No. P43403, P43404
Gene Alias 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; EC 2.7.10.2; FLJ17670; FLJ17679; I79_004087; IMD48; kinase ZAP70; mrtle; mur; Selective T cell defect; Srk; STCD; STD; syk-related protein tyrosine kinase; syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; Tyrosine-protein kinase ZAP-70;TZK; TZK; ZA70; Zap70; ZAP-70; Zeta chain associated protein kinase 70kDa; zeta chain of T cell receptor associated protein kinase; zeta chain of T cell receptor associated protein kinase 70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Gene Symbols ZAP70
Host Species Mouse
Immunogen GST-fusion protein of Human ZAP70, amino acids 282-307.
Purification Method Purified
Quantity 500 μL
Regulatory Status ASR
Primary or Secondary Primary
Gene ID (Entrez) 22637, 7535
Target Species Human, Mouse
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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