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VHL Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA513487

Code : LE

Additional Details : Weight : 0.01000kg

Product Code. 10008919

  • £436.00 / 100µg
Estimated Shipment: 18-06-2024
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Description

Description

This antibody is predicted to react with rat based on sequence homology.

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Specifications

Specifications

VHL
Polyclonal
Unconjugated
VHL
elongin binding protein; HRCA1; Protein G7; pVHL; RCA1; VHL; VHL1; VHL19; Vhlh; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog; von Hippel-Lindau tumor suppressor; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Rabbit
Antigen affinity chromatography, Protein A
RUO
22346, 7428
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
P40337, P40338
VHL
KLH conjugated synthetic peptide between 43-71 amino acids from the N-terminal region of human VHL
200 μL
Primary
Human, Mouse
Antibody
IgG
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