Invitrogen™ TLR2 Monoclonal Antibody (TLR2.45), Biotin

Product Code.	Quantity	unitSize
10049493	50 μg	50µg

Product Code. 10049493 Supplier Invitrogen™ Supplier No. MA140319

Description

Mouse Monoclonal Antibody

MA1-40319 detects TLR2 from human samples. MA1-40319 has been successfully used in immunofluorescence and flow cytometry applications. The MA1-40319 immunogen is a proprietary sequence.

TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

Specifications

• Antigen: TLR2
• Applications: Flow Cytometry, Immunocytochemistry
• Classification: Monoclonal
• Clone: TLR2.45
• Concentration: 0.1 mg/mL
• Conjugate: Biotin
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide
• Gene: Tlr2
• Gene Accession No.: O60603
• Gene Alias: CD282; Ly105; TIL4; Tlr2; TLR-2; toll like receptor 2; toll/interleukin-1 receptor-like protein 4; Toll-like receptor; toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; toll-like-receptor 2, exon 1a_; Toll-like-receptor, exon 1b; Toll-like-receptor, exon 1b_; Toll-like-receptor2, exon 1a
• Gene Symbols: Tlr2
• Host Species: Mouse
• Immunogen: Human Flag-tagged TLR2.
• Purification Method: Protein G
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7097
• Target Species: Human
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1