Invitrogen™ STAT5 beta Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ 712500

Product Code. 10038162

Description

STAT5 beta Polyclonal Antibody for Western Blot, IHC (P), IP, ChIP, ELISA, GS

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Specifications

• Antigen: STAT5 beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Stat5b
• Gene Alias: LOC101122961; mammary gland factor STAT5B; Signal transducer and activator of transcription 5a; signal transducer and activator of transcription 5B; STA5B; STAT; STAT5; STAT5B; transcription factor STAT5B
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20851, 25126, 6777
• Content And Storage: -20°C
• Form: Liquid

• Applications: ChIP Assay, ELISA, Gel Shift, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: P42232, P51692, P52632
• Gene Symbols: Stat5b
• Immunogen: Peptide corresponding to the C-terminus of murine Stat5b coupled to protein carrier.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG